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I always thought of orpheus as just jet black magic heroin. Not as cool sounding as the other ideas, but easier to make.

That kinda sounds like the drug Pigment (nicknamed black heroin) from the Orpheus Rpg. It had nothing to do with vampires but everything with ghosts. People who are under influence of it can see ghosts (they usually think they are hallucinations). And after they die Pigment junkies almost always became ghosts themselves.